BindingDB BDBM50505542 CHEMBL4576489

BDBM50505542 CHEMBL4576489

SMILES [H][C@]12C[C@H]([C@@H](OC)[C@](C)(O1)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F

InChI Key InChIKey=OSVUGUHRKMMBSE-INMRTLOZSA-N

Data 179 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50505542

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50505542(CHEMBL4576489)

Kd: 41nMAssay Description:Binding affinity to recombinant human full-length N-terminal GST-tagged SYK expressed in baculovirus expression system using Blk/Lyntide as substrate...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Filter my 179 hits

Targets 179▿
- Tyrosine-protein kinase Tec 1
- Peripheral plasma membrane protein CASK 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 1
- Receptor tyrosine-protein kinase erbB-4 1
- BMP-2-inducible protein kinase 1
- Rhodopsin kinase GRK1 1
- Tyrosine-protein kinase FRK 1
- LIM domain kinase 1 1
- Hepatocyte growth factor receptor 1
- ALK tyrosine kinase receptor 1
- NUAK family SNF1-like kinase 2 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Glycogen synthase kinase-3 alpha 1
- Glycogen synthase kinase-3 beta 1
- Protein kinase C iota type 1
- NUAK family SNF1-like kinase 1 1
- AP2-associated protein kinase 1 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1
- MAP/microtubule affinity-regulating kinase 3 1
- Homeodomain-interacting protein kinase 4 1
- Protein kinase C theta type 1
- Homeodomain-interacting protein kinase 3 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase PAK 4 1
- Serine/threonine-protein kinase PAK 5 1
- Serine/threonine-protein kinase PAK 6 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk1 1
- Serine/threonine-protein kinase Sgk3 1
- Ephrin type-A receptor 1 1
- Serine/threonine-protein kinase 38-like 1
- Myosin-IIIb 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 7 1
- Myotonin-protein kinase 1
- Tyrosine-protein kinase ITK/TSK 1
- Tyrosine-protein kinase receptor UFO 1
- Cyclin-C 1
- Protein kinase C eta type 1
- Tyrosine-protein kinase Blk 1
- Serine/threonine-protein kinase 16 1
- Non-receptor tyrosine-protein kinase TNK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Homeodomain-interacting protein kinase 2 1
- Ribosomal protein S6 kinase beta-1 1
- Protein kinase C beta type 1
- Tyrosine-protein kinase Lyn 1
- Serine/threonine-protein kinase 26 1
- Focal adhesion kinase 1 1
- Serine/threonine-protein kinase 24 1
- Serine/threonine-protein kinase 25 1
- Serine/threonine-protein kinase 33 1
- cAMP-dependent protein kinase catalytic subunit gamma 1
- Activated CDC42 kinase 1 1
- Platelet-derived growth factor receptor beta 1
- Epithelial discoidin domain-containing receptor 1 1
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 1
- Death-associated protein kinase 2 1
- Death-associated protein kinase 1 1
- Tyrosine-protein kinase Fer 1
- Serine/threonine-protein kinase D2 1
- TGF-beta receptor type-2 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1
- Death-associated protein kinase 3 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase TAO1 1
- Calcium/calmodulin-dependent protein kinase kinase 1 1
- Serine/threonine-protein kinase TAO3 1
- Calcium/calmodulin-dependent protein kinase kinase 2 1
- Serine/threonine-protein kinase DCLK3 1
- Testis-specific serine/threonine-protein kinase 1 1
- Serine/threonine-protein kinase TNNI3K 1
- Angiopoietin-1 receptor 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Protein kinase C epsilon type 1
- Mitogen-activated protein kinase kinase kinase kinase 1 1
- Serine/threonine-protein kinase MRCK alpha 1
- Mitogen-activated protein kinase kinase kinase kinase 5 1
- Mitogen-activated protein kinase 15 1
- Testis-specific serine/threonine-protein kinase 3 1
- Leukocyte tyrosine kinase receptor 1
- Interleukin-1 receptor-associated kinase 4 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Mitogen-activated protein kinase kinase kinase 9 1
- RAC-gamma serine/threonine-protein kinase 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Interleukin-1 receptor-associated kinase 1 1
- Tyrosine-protein kinase ABL2 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Mitogen-activated protein kinase kinase kinase 2 1
- Cyclin-C/Cyclin-dependent kinase 19 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- cGMP-dependent protein kinase 2 1
- Rho-associated protein kinase 2 1
- cGMP-dependent protein kinase 1 1
- Rho-associated protein kinase 1 1
- Serine/threonine-protein kinase ULK1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Tyrosine-protein kinase Fes/Fps 1
- Serine/threonine-protein kinase SIK2 1
- Myosin light chain kinase, smooth muscle 1
- Serine/threonine-protein kinase SIK1 1
- Serine/threonine-protein kinase ULK2 1
- Serine/threonine-protein kinase ULK3 1
- Serine/threonine-protein kinase 3 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Serine/threonine-protein kinase 17A 1
- Tyrosine-protein kinase Lck 1
- Serine/threonine-protein kinase 4 1
- Dual specificity protein kinase CLK1 1
- CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 1
- Mitogen-activated protein kinase kinase kinase 14 1
- Protein kinase C delta type 1
- NT-3 growth factor receptor 1
- Mitogen-activated protein kinase 9 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK2 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- High affinity nerve growth factor receptor 1
- Serine/threonine-protein kinase N2 1
- cAMP-dependent protein kinase catalytic subunit beta 1
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 1
- Mitogen-activated protein kinase 8 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-2 1
- Tyrosine-protein kinase SYK 1
- Ribosomal protein S6 kinase alpha-3 1
- Ribosomal protein S6 kinase alpha-1 1
- Serine/threonine-protein kinase TBK1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- STE20-like serine/threonine-protein kinase 1
- Calcium/calmodulin-dependent protein kinase type 1G 1
- Fibroblast growth factor receptor 4 1
- Serine/threonine-protein kinase 32B 1
- Serine/threonine-protein kinase 32A 1
- Serine/threonine-protein kinase 32C 1
- Vascular endothelial growth factor receptor 2 1
- Tyrosine-protein kinase Fgr 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 3 1
- Tyrosine-protein kinase HCK 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Fibroblast growth factor receptor 3 1
- Serine/threonine-protein kinase PLK4 1
- Mitogen-activated protein kinase 12 1
- Tyrosine-protein kinase receptor TYRO3 1
- RAC-beta serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 10 1
- Serine/threonine-protein kinase BRSK1 1
- Protein kinase C gamma type 1
- Serine/threonine-protein kinase LATS2 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Citron Rho-interacting kinase 1
- Ribosomal protein S6 kinase alpha-6 1
- Protein kinase C alpha type 1
- Ribosomal protein S6 kinase alpha-5 1
- Maternal embryonic leucine zipper kinase 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase MARK2 1
- TRAF2 and NCK-interacting protein kinase 1
- Tyrosine-protein kinase Yes 1
- Mitogen-activated protein kinase kinase kinase 11 1
Publications 1▿
- Bioorg Med Chem Lett 29: (2019) 179
Institutions 1▿
- Takeda Pharmaceutical 179
Affinity: 2 to 2.0E+3 nM▿
- Kd 179
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0